Pharmacogenomics for greater patient care

You probably know that different people have different enzyme levels; but did you know that these will in turn affect how your body metabolises medication?

These are individuals young and old who have little to no CYP2D6 metabolic enzyme. That means when they take medicines which are metabolised through these enzymes, they will build up in the person's body and accumulate causing a number of issues.

The flip side of those who metabolize too slowly or not at all, is those who metabolize too quickly.  They have very high to very high levels of CYP2D6 enzymes. This causes the medication to have brief or not any effects due to the fast elimination leading to reduced effectiveness.  

At DD Pharmacotherpay and Nkepah Pharmacy, our expert pharmacists believe that true health involves more than just taking medication blindly. Even when prescribed, you have to advocate for yourself to your doctors. Don't let them guess.  

"Don't guess, do the test" is our slogan. That's why we offer a wide range of health and wellness screenings and services including a pharmacogenomics test.  Do this first, before starting any chronic or acute medication therapy. The PGx test is only needed once in your lifetime to know where you fall as a normal, slow, rapid or intermediate metabolizer. 

Every day someone dies from preventable medication harm. You don't have to be next. 

 Cytochrome P450 (CYP450) are a family of metabolic enzymes encoded by the P450 genes and responsible for the metabolism of most medicines seen in clinical practice. 90% of medicines are metabolised by CYP3A5, CYP3A4, CYP2D6, CYP2C19, CYP2C9 and CYP1A2. 

CYP3A4 and CYP2D6 are the most significant enzymes for your wellness.

In addition:

Some medicines are CYP inducers, meaning these medicines increase the CYP activity. 

Some medicines are CYP inhibitors, meaning these medicines decrease the CYP activity.

It becomes extremely important to have these checked, know what classification you fall under, and to how your medicines are truly affecting you. 

No action: perpetual gamble with metabolic issues and possible hospitalizations / death

Lifetime Cost of PGx test (once-off): R3500

Annual MTM360: R500 (promo); R1000 normal price

We're here to help.

Contact us by phone, email, or in person, and our friendly staff will be happy to assist you. We look forward to serving you!

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The first MTM practice in South Africa is now open! 

We believe in personalized patient care and will go the long way to ensure everyone who walks through our doors or books online, receives the best. If you require accompaniment on your healthcare journey or want to be a step ahead in your future health status...  let us assist you. With our many services including these 2 exclusive ones:

👌 PREV360 - 1hour personalized full body screening (recommended twice / year)
👌 MTM360 - 1hour full pharmacotherapy reset (recommended once / year) 

... you will have confidence and assurance in your healthcare decisions going forward. 

Plan for the future, protect your internal tissue and organs and those of your family for a healthier future with our extensive and expanded full body screenings and associated health action plans. We also offer the following excellent services:

💊 Wheelchair hire
💊 Chronic Support group (Diabetes/ Hypertension/CV conditions/HIV/etc.)
💊 Acute medicine and supplementation advice
💊 Chronic medicine and professional advice
💊 Patient Transport + Deliveries
💊 After hour callouts & Home visits
💊 PCDT (primary care drug therapy) consultations + prescriptions
💊 In person and online (remote) consultations
💊 Structured referrals + documentation + follow ups
💊 Custom Wellness talks & Days (workplace + schools)
💊 Extensive Screenings (blood uric acid, blood glucose, blood pressure, cholesterol, iron, gluten, body composition, urine analysis, STIs, HIV, pregnancy, paternity, etc.) 

From durable medical equipment, home sharps bins, to insulin pen cases/ ice packs, and many others; we sell practical health-enhancing practical items needed for optimized living & managing your health at home with all convenience. Our knowledgeable staff can help you find the products you need to stay comfortable and safe.

If you require support and wish to connect with others facing similar health challenges as you; then join one of our support groups:

-Active + Fitness Support

-Metabolics + Diabetics Support

-Cardiovascular Support 

-Mental Health Support 

-New Mothers Support

-HIV / AIDS Support 

among others,  you may also initiate one if you are a creative leader in your community or area. 

Never miss a dose with our easy prescription refill service. Simply provide your prescription information, and we'll have your medication ready for pickup or delivery. Plus, our pharmacists are always available to answer any questions you may have about your medications. They also conduct a unique preventive care questionnaire with all patients to highlight key elements that enhance healthcare outcomes. 

Move your repeat and chronic prescriptions to us and get a free MTM360 session in May 2025

At Nkepah Pharmacy - DD Pharmacotherapy practice, we believe that true health involves more than just taking medication when ill.  True wellness is holistic + preventive. It includes multiple interventions while excluding dangerous practices and habits. That's why we offer workplace / corporate and school appropriate wellness day or event packages.  Customized educational talks, preventive plans, screenings and supplementation for all attendees. 

Book a month in advance for optimal delivery. 

Most times, one-size-fits-all medication regimens just don't cut it. We know that peeple are unique individuals  and require optimization in their pharmacotherapies and health plans in order to address individual susceptibilities, and prevent unnecessary health decay, hospitalizations and even death. 

MTM360 is our unique pharmacotherapy reset service - when last did you get a review of all your OTC, prescription, traditional, and complementary medicines? Are all your prescribers aware of each others' prescriptions? Have you had a streamlined manged regimen to include all the necessary therapies by the hour in your daily routine?  Its an educational, insightful and simplified 1-hour RESET that everyone should experience at least once a year. 

book here (012 035 1221)

We're here to help with all of your pharmacy needs. Contact us by phone (012 035 1221), email (ddpharmacotherapy@pharmers.co.za), or in person (Raslouw Wellness Center, Centurion), and our caring professionals will be happy to assist you. We look forward to serving you!